Results
| PMID | 20825374 |
| Gene Name | TNF |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 75 |
| Population details | 28 infertile women with endometriosis (study group), 23 women with fallopian-associated infertility (controls), and 24 women with myoma (controls) |
| Sex | Female |
| Infertility type | Female infertility |
| Associated genes | Leptin, MCP-1, andTNF-alpha levels |
| Other associated phenotypes |
Endometriosis-associated infertility |
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Am J Reprod Immunol. 2011 Apr;65(4):403-6. doi: 10.1111/j.1600-0897.2010.00920.x. Tao, Yu| Zhang, Qiang| Huang, Wei| Zhu, HuiLi| Zhang, Dongxue| Luo, Wanying Department of Obstetrics/Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China. PROBLEM: To explore the roles of leptin, monocyte chemotactic protein (MCP)-1, and tumour necrosis factor (TNF)-alpha in the peritoneal fluid (PF) in the pathogenesis of endometriosis-associated infertility. METHOD OF STUDY: Leptin, MCP-1, and TNF-alpha levels in the PF from 28 infertile women with endometriosis (study group), 23 women with fallopian-associated infertility (controls), and 24 women with myoma (controls) were determined by performing enzyme-linked immunosorbent assay (ELISA). RESULT: Leptin and TNF-alpha levels in the PF showed no significant difference among three groups. The MCP-1 level in patients with endometriosis was higher than those in fallopian-associated infertility group and myoma group (P < 0.01). There was a positive correlation between leptin and MCP-1 levels in the PF of patients with endometriosis (P < 0.05). CONCLUSION: Peritoneal leptin and MCP-1 play important roles in the pathogenesis of infertility in the early stage of endometriosis. Mesh Terms: Adult| Ascitic Fluid/chemistry/pathology| Chemokine CCL2/*metabolism| Endometriosis/complications/*immunology/*metabolism| Enzyme-Linked Immunosorbent Assay| Fallopian Tubes/pathology| Female| Humans| Infertility, Female/*etiology| Leptin/*metabo |
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